Could A Malaria Vaccine Be On The Way?

malaria
USAID and the President’s Malaria Initiative support the distribution and use of bednets to protect against malaria. Bednets are important for children and pregnant women who are most vulnerable to the disease. Photo: Alison Bird/USAID

The UK drug company GlaxoSmithKline is applying for regulatory approval of the world’s first malaria vaccine, the BBC reports.

The move comes after tests that the company said were promising. For the past several years, GlaxoSmithKline has conducted tests of its vaccine on almost 15,500 children in seven African countries. The company reports that 18 months after vaccination, there was a 27 percent reduction in malaria cases in infants aged 6-12 weeks and a 46 percent reduction in children aged 5-17 months.

Now it’s applying to the European Medicines Agency to start marketing the vaccine. GlaxoSmithKline’s research was supported by the Bill and Melinda Gates Foundation and the company says it will make the vaccine affordable for poorer nations.Ninety percent of the world’s malaria cases are in the poorer regions of sub-Saharan Africa where the vaccine was tested. Globally, malaria kills 800,000 people a year. It’s also a major hazard for adventure travelers. While antimalarial pills are generally effective, they can have serious side effects. A vaccination would go a long way to easing the burden on people who choose to visit the tropics.

Approval for the vaccine could come in 2014. Unfortunately, the percentages the company is quoting do not indicate that it will be as effective as many of the vaccines we are used to. Other measures are still needed like the education of the public of the dangers of standing water and the need to use mosquito netting. More innovative methods for fighting the disease like infecting them with bacteria are also being studied.

Hopefully GlaxoSmithKline’s vaccine will be just the first generation of a series of improving vaccines that will one day relieve the world of a dangerous disease.

Fight Against Malaria Takes Odd New Turn

malaria
A new study has found a possible way to stop at least one species of mosquito from giving you malaria – by infecting them with a special strain of bacteria.

Researchers have found that infecting mosquitoes with the Wolbachia bacterium makes it nearly impossible for malaria to survive in the insects, thus keeping them from spreading it to humans, the BBC reports. The technique was tested on Anopheles stephensi, a species that ranges from the Middle East to Asia. An example is shown here in this Wikimedia Commons image. This remarkable photograph shows the insect sucking blood from a human. It’s become so engorged it’s actually ejecting extra blood from its rear end. Sorry if you were eating when you saw this but hey, it’s in the name of science.

The bacteria passed from female mosquitoes to their offspring, opening up the possibility of infecting the entire species. Researchers followed 34 generations of infected mosquitoes and found the bacteria passed on through all of them. The results have been published in the journal Science. A study last year showed the same bacteria can be used to stop dengue fever.

The technique has not yet been tried on Anopheles gambiae, the main source of malaria in Africa.

This potential breakthrough in the fight against malaria is coming along at an important time, now that mosquitoes are developing a resistance to DEET.

Travel Smarter 2012: Travel tips for health and wellness

Films like “Contagion” (which I very much enjoyed, and not just because Gwyneth Paltrow bites it within the first 10 minutes) instill a paranoia in the public consciousness about the hazards of air travel. It’s true, however, that most public transportation is the equivalent of a mobile petri dish; one can’t deny the inherent germiness lurking within. Subsequently, antibacterial hand gel is my new best friend.

There are other quasi-self-inflicted, travel-related maladies: neck and back pain, deep vein thrombosis (DVT), infectious disease, foodborne illness, stress–all of which kind of make you wonder why we travel in the name of relaxation, but I digress.

For many, myself included, part of the thrill of recreational travel is the element of risk involved, even if said danger involves nothing more than scarfing down a few street tacos. Regardless of why you travel, there are always new products on the market designed to make your trip more comfortable, or minimize your chances of getting sick. New research on the hazards and benefits of travel also keep us informed about what we can do to stay healthier on the road.

Below are my picks for making travel in 2012 a little less treacherous:

1. Reduce your risk of DVT
New studies show that choosing the window seat on a long flight can increase your chances of developing DVT. A theoretical DVT risk known as “economy class syndrome” (how’s that for an “f-you” to airlines?) has been debated for years, and attributed to the lack of legroom in coach.

Now, however, the American College of Chest Physicians have determined that the real issue is that window-seat fliers have limited opportunities to walk and stretch their legs during lengthy flights, which can lead to potentially fatal blood clots that may travel to the lungs (pulmonary embolism). There are a number of factors that contribute to one’s risk of DVT including age, preexisting health conditions, certain medications, and recent surgery, but even if you don’t fit these criteria, you should always try to get out of your seat and/or do some stretching exercises and leg movements once an hour during long flights. In other words, consider the aisle the path to clot-free veins.

2. Time-release DEET
Some people have no problem dousing themselves in insecticide, personal health and environmental side effects be damned. I used to silently sneer at those people while I sat around the campfire, my unprotected skin providing nutrients to legions of winged, blood-sucking creatures. What were a few bites (Note: it was never just a few bites; try dozens) compared to not getting cancer or maintaining the purity of the local watershed?

Then I got sick as a result of deadly bacteria-harboring sandflies, and now I’m one of those people who understand why DEET exists. I still don’t like it–it’s definitely not something I, nor the CDC, recommend using with abandon–but it’s critical for protecting yourself from mosquitoes, sandflies, ticks, and other potentially harmful insects, in conjunction with protective attire such as long socks, long-sleeved shirts, and pants (you can also purchase insect-repellent clothing). Note that I’m not taking into account malarial conditions, in which case you should be supplementing your DEET applications with a doctor-prescribed anti-malarial drug.

I was thrilled when I recently discovered controlled release DEET at my neighborhood travel store. Sawyer® Premium Controlled Release Insect Repellent is designed to “reduce the rate of DEET absorption” by 67% per application, and “extend the duration of its effectiveness.” This 20% DEET lotion is also odorless, so you don’t have to huff noticeably toxic fumes all day.

3. Hummingbird Lumbar Pillow
If you have existing back problems or an epic backpacking adventure planned, this little baby from innovative gear company Hummingbird is the bomb. Measuring 7″ x 14″, it weighs just 3.5 ounces, rolls or packs flat, and will keep your lower back happy while camping, or riding a Third World bus sans shock absorbers on a rutted highway with potholes large enough to swallow a Mini Cooper.

4. Simply Being Guided Meditation app
I’m way too ADD to meditate, but this suggestion came to me from my Gadling colleague, and fellow meditation-phobe, McLean Robbins. She loves this app, which runs through a brief series of relaxation exercises. As McLean says, “Perfect for shutting out the world on a terrible plane ride or easing into sleep in an unfamiliar hotel bed.” The app is available for iPhone, iPad, Blackberry, and Android.

5. Maqui berry
Move over, açaí, there’s a new free-radical fighter in town. Chilean maqui berry, which is FDA-approved and contains the highest ORAC (a system of measure for antioxidants) level in the world, has hit the U.S. Only a few companies manufacture it, but I recommend Isla Natura brand (Full disclosure: the company is owned by a friend of mine, which–in addition to maqui’s health benefits–is why I feel comfortable touting this product). Maqui (Aristotelia chilensis) is indigenous to southern Chile and was traditionally used by the Mapuche Indians as a medicinal aid.

Isla Natura’s USDA and EU-certified organic (Fair Trade certification pending) wild fruits are harvested by hand, dried, ground, and sold in eight-ounce packets. Use one tablespoon in smoothies or on top of yogurt or oatmeal as a daily dietary supplement, but also consider it an immune booster for when you’re traveling.

Bonus: you’ll avoid the high sugar content of Emergen-C, and the “licking a dirt floor” flavor of açaí, and Isla Natura provides employment to local indigenous families at its small Chiloe processing plant. Travel-friendly capsules will be available in April; go to the company’s website for information on scientific studies. To order, click here.

[flickr image via viajar24h.com]

Ten bizarre travel diseases that can ruin your next vacation

travel diseasesOn some level, catching a weird disease or picking up a little-known tropical parasite on your travels gives you bragging rights. “Look at me, I’m so hardcore!” Trust me, I’ve been there. But with Multidrug-Resistant Tuberculosis (MDR TB) making headlines worldwide, I’d like to remind fellow travelers that these diseases are no joke, and even those of us with healthy immune systems and access to industrialized medicine aren’t impervious.

The reality is, you never know what you might be susceptible to. In my case, my doctors and medical research indicate that I may be lacking an enzyme that made me vulnerable to an extremely rare but serious tropical disease caused by the bacteria Bartonella bacilliformis, which causes Oroya Fever (and its precursor, Verruga Peruana). I’m still recovering from a three-year battle with the disease that has resulted in permanent organ damage because of a failure to protect myself against sand flies in the Amazon Basin region of Ecuador. Regular applications of DEET could have prevented that, as well as the various misdiagnoses of tuberculosis, histoplasmosis, and Hodgkin’s lymphoma, but that’s another story.

A lot of tropical and uncommon travel-related ailments are difficult to diagnose, and sometimes even more problematic to cure (if they don’t kill you, first). Statistically, however, most travelers–even if they’re in extremely sketchy parts of the world–will stay healthy if they take the necessary precautions. Having a trustworthy travel doctor is also helpful if you spend a lot of time in developing nations.
Being prepared before you leave home is key. You should never take travel wellness lightly, but don’t let fear ruin your trip. I certainly don’t follow every bit of medical advice out there (I honestly don’t see the point of traveling if not to eat epic quantities of street food.). If you’re going to be completely paranoid and don’t own a Hazmat suit, perhaps it’s better to stay home. But don’t ignore CDC warnings for recommended (or required) vaccinations, and if you know you’re going to be in a malarial or otherwise-dangerous insect-or-disease-inhabited region, prepare accordingly.

Just remember to do your research before you go, and remember that while it most likely won’t happen to you, it’s not impossible.

After the video (graphic, but it illustrates just how devastating TB can be, as well as provides important information on Multidrug-Resistant Tuberculosis), a gallery of bizarre diseases you’ll want to avoid during your travels.


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Travel health gift guide: what to get the incessant wanderer on your list

travel healthTravel junkies are a special breed. Only a very distinct personality type gets a rush from being on the road as much as possible, or relishes the discomforts and situations most people go to lengths to avoid. Homesickness is a foreign concept.

I know, because I too suffer from this malady. It started early, because I have a vivid memory of bursting into tears when I was six or seven, after we dropped a friend off at the airport.

“What’s wrong?” my dad asked. “I’m sad because we’re not getting on an airplane,” was my reply (ironic given my aviophobia, which had its onset about 12 years later).

A paralyzing fear of air travel hasn’t stopped me from roaming, however. So, whether you have a loved one who practically lives at Club Med or one actually enjoys sleeping on the ground or in janky Third World hostels rife with cockroaches…lucky you. You have a travel addict in the family or as a friend.

One experience incessant wanderers don’t go looking for? Illness or injury. While not inevitable, the more time you spend abroad, the greater the likelihood of suffering from anything from an infected bug bite or Bali Belly to…worse. But as I’ve always said, you can get hit by a bus crossing the street.

Of course travel isn’t inherently unsafe, but there are precautionary measures that minimize the odds of having health issues on the road. Below, my road-tested gift picks for frequent travelers (especially those who visit sub-tropical or tropical climes) and outdoor enthusiasts.

SteriPEN or LifeStraw portable water filter
Reasons why one of these is a worthwhile investment:

  • Saves money on purchasing bottled water in developing nations/places without potable water
  • Better for the environment (see above)
  • You can contract giardia or other nasties from improperly “bottled” water (trust me)
  • You don’t have to be out in the backcountry to have a potable water shortage; owning a filtration system is good insurance you stay hydrated and healthy, even in the city.

[Photo credit: Flickr user fauxrealphotos]travel healthTravel first aid kit
Even infrequent travelers should carry basic first-aid supplies: band-aids, gauze pads, Neosporin, OTC meds, etc.. Personalize your gift by tailoring a pre-purchased kit (REI is a great place to find different types and sizes) to suit the interests and needs of your recipient.

Wilderness first aid class
CPR or a general first aid class is a good idea for anyone, but if any of your loved ones live for backcountry pursuits or traveling off the beaten path, a WFA course can be a lifesaver–literally. Look one up in your area through the American Red Cross.

Controlled-release DEET and/or Insect Shield apparel
There was a time, several years ago, when I shunned DEET unless I was in a malarial region. Why, I asked myself, would I willingly douse myself in a pesticide? Why would I inflict said poison upon the environment?

That philosophy is all well and good until you get bitten by something harboring an infectious evil (in my case, it was sandflies carrying the Bartonella bacilliformis bacterium) that anti-malarials can’t prevent. Also note that malaria prophylaxis is not without considerable side-effects and may not protect you against certain strains of the disease. Be sure to talk to an infectious disease, tropical medicine, or travel physician experienced with actual working experience in these regions.

These days, I’m all about DEET if I’m traveling somewhere with potentially harmful biting insects, especially now that there are controlled-release versions on the market (there are various brands on the market; Sawyer Products is highly recommended). One application is good for up to 12 hours.

As for clothes, I love my Insect Shield long sleeve button-up shirt from ExOfficio. Good for up to 70 washings (after which you still have a good-looking, lightweight travel top), bug-repelling garments are treated with permethrin, EPA-registered, and free of toxic-smelling fumes.

Sun protective clothing
As you likely know, heat exhaustion or heat stroke can be serious; even fatal. In addition to a good sunblock, sunglasses, and a hat, sun protective clothing is a seriously smart idea for outdoor types. Once again, I recommend ExOfficio, or REI own brand, which will save you a few dollars.

Bear bell or spray
Google “2011 grizzly attacks.” ‘Nuff said.
travel health
SmartWool
socks
What they say in the military is true: you gotta take care of your feet. Once your dogs go, you’re SOL in the backcountry or tropics. Keeping feet clean and dry (and warm, if applicable) is of utmost importance (at the very least, fellow travelers will appreciate your hygiene efforts). These moisture-wicking, stench-resistant socks are invaluable even if you’re just planning an extended trip.

Ibex woolies
Getting chilled can quickly become serious or fatal, and hypothermia prevention in the form of extra layers is key. These 100% merino wool underlayers from Vermont-based outfitter Ibex are the bomb. Comfortable, warm, moisture-wicking, and seriously odor-proof (anything that remains fit to wear in public after a month-long backpacking trip from the Andes to the Amazon–sans laundry–is a product I heartily endorse). Plus, they come in cute stripey designs as well as solids.

[Photo credit: Band-aids, Flickr user m.gifford, feet, Flickr user Cin]

How Deep Vein Thrombosis Develops