Could A Malaria Vaccine Be On The Way?

malaria
USAID and the President’s Malaria Initiative support the distribution and use of bednets to protect against malaria. Bednets are important for children and pregnant women who are most vulnerable to the disease. Photo: Alison Bird/USAID

The UK drug company GlaxoSmithKline is applying for regulatory approval of the world’s first malaria vaccine, the BBC reports.

The move comes after tests that the company said were promising. For the past several years, GlaxoSmithKline has conducted tests of its vaccine on almost 15,500 children in seven African countries. The company reports that 18 months after vaccination, there was a 27 percent reduction in malaria cases in infants aged 6-12 weeks and a 46 percent reduction in children aged 5-17 months.

Now it’s applying to the European Medicines Agency to start marketing the vaccine. GlaxoSmithKline’s research was supported by the Bill and Melinda Gates Foundation and the company says it will make the vaccine affordable for poorer nations.Ninety percent of the world’s malaria cases are in the poorer regions of sub-Saharan Africa where the vaccine was tested. Globally, malaria kills 800,000 people a year. It’s also a major hazard for adventure travelers. While antimalarial pills are generally effective, they can have serious side effects. A vaccination would go a long way to easing the burden on people who choose to visit the tropics.

Approval for the vaccine could come in 2014. Unfortunately, the percentages the company is quoting do not indicate that it will be as effective as many of the vaccines we are used to. Other measures are still needed like the education of the public of the dangers of standing water and the need to use mosquito netting. More innovative methods for fighting the disease like infecting them with bacteria are also being studied.

Hopefully GlaxoSmithKline’s vaccine will be just the first generation of a series of improving vaccines that will one day relieve the world of a dangerous disease.

Ten bizarre travel diseases that can ruin your next vacation

travel diseasesOn some level, catching a weird disease or picking up a little-known tropical parasite on your travels gives you bragging rights. “Look at me, I’m so hardcore!” Trust me, I’ve been there. But with Multidrug-Resistant Tuberculosis (MDR TB) making headlines worldwide, I’d like to remind fellow travelers that these diseases are no joke, and even those of us with healthy immune systems and access to industrialized medicine aren’t impervious.

The reality is, you never know what you might be susceptible to. In my case, my doctors and medical research indicate that I may be lacking an enzyme that made me vulnerable to an extremely rare but serious tropical disease caused by the bacteria Bartonella bacilliformis, which causes Oroya Fever (and its precursor, Verruga Peruana). I’m still recovering from a three-year battle with the disease that has resulted in permanent organ damage because of a failure to protect myself against sand flies in the Amazon Basin region of Ecuador. Regular applications of DEET could have prevented that, as well as the various misdiagnoses of tuberculosis, histoplasmosis, and Hodgkin’s lymphoma, but that’s another story.

A lot of tropical and uncommon travel-related ailments are difficult to diagnose, and sometimes even more problematic to cure (if they don’t kill you, first). Statistically, however, most travelers–even if they’re in extremely sketchy parts of the world–will stay healthy if they take the necessary precautions. Having a trustworthy travel doctor is also helpful if you spend a lot of time in developing nations.
Being prepared before you leave home is key. You should never take travel wellness lightly, but don’t let fear ruin your trip. I certainly don’t follow every bit of medical advice out there (I honestly don’t see the point of traveling if not to eat epic quantities of street food.). If you’re going to be completely paranoid and don’t own a Hazmat suit, perhaps it’s better to stay home. But don’t ignore CDC warnings for recommended (or required) vaccinations, and if you know you’re going to be in a malarial or otherwise-dangerous insect-or-disease-inhabited region, prepare accordingly.

Just remember to do your research before you go, and remember that while it most likely won’t happen to you, it’s not impossible.

After the video (graphic, but it illustrates just how devastating TB can be, as well as provides important information on Multidrug-Resistant Tuberculosis), a gallery of bizarre diseases you’ll want to avoid during your travels.


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Vice TV produces Voodoo and Vaccines in Benin, Africa

Vice TV got our attention a year or so back because of their work producing the best destination and culture videos out in the community. These were the guys that were making guides to North Korea and covering Mongolian yak racing. These guys were the film makers and the story tellers that we aspired to.

Their work has paid off. Among numerous partnerships and work that they’ve got coming down the pipeline, you can now see many Vice videos over at CNN, and the group has cemented a place in the community as leaders in quality, edgy film making.

Vice’s most recent production in collaboration with one.org looks at the challenges and rewards of working with vaccinations in Benin, Africa. It’s a sobering look into the culture of West Africa, and the documentary is a great piece. Take a look at it below.

Knocked up abroad: pregnant travel in the first trimester

pregnant travelFor more on pregnant travel, see parts 1 and 2 of Knocked up abroad: pregnancy in a foreign country here and here.

There’s no question that having a baby changes you: your body, your lifestyle, even your shoe size. One thing I hoped not to change altogether was traveling, as long as it was reasonably safe and comfortable for me and the baby. From the beginning of my pregnancy in Istanbul, my doctor has okayed travel, as long as I get up to stretch frequently on flights and try not to overdo it. Most doctors (and mothers) agree that the second trimester is the most comfortable time for pregnant travel but the first trimester can be a good time as well (while you can still squeeze into pre-maternity clothes and walk without waddling) with a little extra precaution and a little more babying (of the mother, of course).


The first trimester of pregnancy is a tricky time for many women: the risk of miscarriage is highest up to 10 weeks, morning sickness is common, and hormones are running wild. It’s too early to tell anyone outside family or close friends and without a visible belly, it’s impossible for strangers to tell as well. At later points in your pregnancy, a baby bump acts as the international symbol for pregnancy and can make it much easier to express your condition when traveling abroad. If you travel in the early months before showing, you may want to learn the local language words for “I’m pregnant” to avoid a Bridget Jones-esque “mit kinder” scene if you need extra help while traveling.


Over this past December, my husband and I were looking for a good trip to take over the holidays, when I was around 10 weeks pregnant. Our location in Istanbul changes the list of short-haul destinations considerably from what we would have considered from New York, and we debated between a warm-weather beach destination (husband) or a snowy and “Christmassy” European city (me). We ruled out Egypt (not warm enough and not Christmassy), New Zealand (even less convenient to get to than from New York), and Sri Lanka (not enough time to plan properly and some risks of disease I couldn’t be vaccinated against). In the end, we chose…Russia.
Going to Russia in winter while pregnant may seem crazy to some, but for me it made sense: Moscow and St. Petersburg are a few hours from Istanbul by direct flight, my husband speaks fluent Russian in case of any problems, and there was no risk of malaria or eating any food that had spoiled in the sun. While it was cold and snowing during our trip and I couldn’t take advantage of some of Russia’s cold-weather remedies like vodka and saunas, a week in Moscow and St. Petersburg was a perfect mix of exotic and comfortable.

Nearly every cafe had a variety of non-alcoholic and caffeine-free beverages for me to choose from, I even had non-alcoholic sangria, mojitos, and mulled wine in addition to fresh juices and herbal teas. Both cities are beautiful to explore in the snow, with plenty of museums and cafes to warm up in, and the New Year holiday displays made it festive.

If you are planning a trip to a foreign country while pregnant, it makes sense to keep in mind the following guidelines. Always discuss plans with your doctor before booking and err on the side of caution when choosing a destination.

Check airline restrictions – Most airlines allow pregnant women to fly internationally up to 28 weeks, after which you must provide a doctor’s note issued within a week or so of departure. 35 weeks (earlier for women carrying multiples) is the cutoff for nearly all airlines to prevent women from giving birth on board. Most US domestic carriers will allow pregnant women to fly up to the final month; hilariously, Continental will not let women board if “physical signs of labor are present” though they don’t specify what.

Consider travel insurance – If your medical insurance doesn’t cover you overseas, you may want to look into supplementary medical travel insurance, but be sure it covers pregnancy as many policies do not. Additionally, if you are traveling to a country where English is not spoken, you may want to research the name of a clinic or doctor in case of emergency as well.

Be prepared for jet lag – Before pregnancy, I had little issues with jet lag, trying to get on local time as soon as possible. I discovered when flying back from the US to Turkey that it hits you much harder as a pregnant traveler, especially as you can’t use sleeping pills or alcohol to help you sleep. Factor this into your schedule and give yourself plenty of time to acclimate and adjust to time changes.

Realize your limits have changed – On a usual trip, I’d be up early to walk around a city all day, have a late lunch (or maybe just a big afternoon beer) followed by more museums and exploration, and still be up for checking out the local nightlife. Once pregnant, I required more sleep and three solid meals a day (plus maybe some snacks, I am eating for two!), tired after walking short distances, and was ready to call it a night long before last call. If you have an itinerary, pare it down to the must-sees and double the time to see everything; better to take it easy and enjoy your trip than feel exhausted and sick.

Look for destinations that don’t require vaccinations – One of the first tests your doctor will give you after confirming pregnancy will be for immunizations to hepatitis and rubella. If you haven’t had the vaccines, they will have to wait until after the baby is born as they are not safe for pregnant women. I have not had the hepatitis vaccine yet, and thus have a greater risk of contracting it, which rules out much of Africa and southeast Asia for travel, but also means I must avoid raw vegetables including salad in Istanbul. Most other medications and vaccines commonly given to travelers before going to an area prone to Malaria, Typhoid or Yellow Fever are not advised for pregnant women. But there’s still a big world out there, check the CDC for destination-specific information.

Be extra aware of food and water safety – Pregnant women are more susceptible to food poisoning the average person, as the immune system is suppressed so it doesn’t reject the fetus. This is the reason most pregnant women are told to avoid sushi and food that is not prepared in sanitized conditions. Even adventurous eaters should play it safe while pregnant and drink bottled water when in doubt. I recently had an opportunity to visit Mumbai, India but after consulting with a few friends who had lived there, I worried I’d spend the trip inside my hotel room eating pre-packaged food. Again,

check the CDC and use the same common sense you’d use anytime while traveling: stick with food that is freshly prepared in restaurants full of people.


Stay tuned for more on pregnancy travel, including Turkish superstitions and customs, travelling in the second trimester, where to do pre-baby shopping, and more on having a baby in a foreign country. Check here for further updates.

[Photo courtesy Mike Barish from the Istanbul tram]

Knocked up abroad: getting pregnant in a foreign country

pregnant in a foreign country My first clue that something was different came when I woke up one night on vacation in Kiev at 3am, proceeded to eat 3 slices of toast with caviar spread, went back to bed and woke up a few hours later wondering if they made blueberry muffins in Ukraine (tragicially, they do not). That “time of the month” hadn’t happened but flying tends to always mess with your body, so I didn’t give it much of a thought. Since moving to Istanbul from New York in May 2010 for a work project, my husband and I take frequent trips around Eastern Europe (see my Weekending posts) and that week we spent exploring Kiev and Warsaw while Turkey celebrated Kurban Bayramı (the Muslim festival of sacrifice).

When we arrived back home in Istanbul a few days later, I dug out the Turkish pregnancy test I had purchased a few months earlier after a previous false alarm. Though the instructions were in Turkish, peeing on a stick is fairly universal, and the “POZITIF” results were hard to misinterpret. Excited and nervous to be pregnant in a foreign country, my husband and I wondered what a mountain of paperwork we’d have to provide U.S. Customs in 9 months, what the medical system in Istanbul would be like, and if we could get away with having a baby in Turkey not named in some way for Mustafa Kemal Ataturk, father of modern Turkey and namesake for millions of Turks. Being pregnant in a foreign country is the ultimate way of “going native,” the most “authentic” travel experience you can have. It’s also challenging, sometimes scary, and limits where you can travel, but can be a great way to discover a culture, their hospitality, and traditions.Once I confirmed that I was in fact hamile with bebek, I noticed how child-friendly Turkey is, though not without challenges for the expecting expat. I could only find one English-language pregnancy book (co-written by Oprah’s fave, Dr. Oz, who is of Turkish descent), I’ve heard C-sections are pushed on many women as the only option for childbirth, and I’ve found maternity clothes are mostly limited to childish t-shirts and denim overalls. Turkey’s also a dream for the pregnant traveler: fresh fruit juice is cheap and easy to find at most cafes, vaccinations aren’t needed to visit, and Turks treat pregnant women with the utmost respect and care.

Having a baby, especially a first, in a foreign country isn’t for everyone. My family and support system is far away and I don’t know where to go for things I can find easily in my hometown. My doctor speaks excellent English but many of the nurses and hospital staff do not, and my Turkish is hardly fluent enough to cover every situation. Though the cost of domestic help is low, I’m not sure I want a lady with whom I can’t fully communicate telling me how to raise a baby.

Pregnancy also changes how you look at travel, both where you go and how you do it. I’ve been fortunate not to have morning sickness, but I’m just as at risk for disease as other pregnant women and have to weigh the risks of visiting countries with suggested vaccinations or food- and water-borne illnesses. Growing a baby is tiring work, and it’s hard to reconcile my usual travel self (lots of walking, few breaks) with my pregnant self (tired and hungry almost all the time). The best part about pregnancy travel is learning how each culture values pregnant women and mothers, hearing childbirth experiences from locals and foreigners, and seeing how kind strangers really can be. And all the food cravings help you discover the local cuisine, too.

Stay tuned for more on pregnancy travel, including Turkish superstitions and customs, the lowdown on prenatal medical care in Istanbul, where to travel in each trimester, what to eat when pregnant abroad, and more on having a baby in a foreign country. Check here for further updates.