Big in Japan: How to clone a woolly mammoth

In honor of the recent passing of Michael Crichton, today’s posting is all about cloning…

Believe it or not, Jurassic Park may in fact be a reality sometime in the near future. Of course, we’re talking about the cloning parts of the books and films, not the Hollywood parts where the dinosaurs rampage, and eat pesky humans in equally horrific and amusing ways!

Last week in Japan, healthy mice were cloned from the cells of dead mice that had been frozen for 16 years. This groundbreaking scientific research raises the possibility that endangered – or even extinct – species could be cloned from old carcasses that have been tossed in freezers or found in permafrost, rather than from living cells.

When asked about the possibility of one day resurrecting a woolly mammoth, Teruhiko Wakayama of the RIKEN Center for Developmental Biology in Kobe, who led the research, elegantly stated: “It would be very difficult, but our work suggests that it is no longer science fiction.”

How awesome is that?

Let’s start with the basic question that is most likely on all of your minds – how the hell did they do it?

In simple layman’s terms, the Wakayama team took a nucleus from dead mouse tissue that had been frozen and later thawed, and then injected this into a mouse egg that had its nucleus removed. The resulting embryo was then used to create embryonic stem cells, the nuclei of which were then injected into other eggs to produce clones.

With me so far?

Here is the coolest part: the Wakayama team discovered that it was easiest to create clones from brain tissue, even though clones have never been created from living brain cells. Wakayama believes that freezing and thawing the tissue facilitates the ‘reprogramming’ of the brain cell nucleus.

So what does this all mean?

Most zoos do not have the money or the facilities to collect and cells from every part of every animal, nor to freeze them in such a way as to preserve their viability. However, the Wakayama team has provided evidence that you might be able to simply freeze the corpses of endangered animals, and save their DNA for a rainy day.

Just ask Robert Lanza of Advanced Cell Technology in Worcester, Massachusetts: “With a kitchen freezer you could store the genetic diversity of every panda in existence.”

And now, the ‘mammoth challenge!’

Bringing extinct animals back to life would be much, much trickier, especially since recovered woolly mammoth carcasses would most likely have frozen and thawed several times over the millennia. These processes cause quite a bit of damage to cell nuclei, and limit the chances that a viable clone could survive.

However, it may in fact be possible, and these latest findings are extremely, extremely positive!

So, it’s very likely that you’ll more about the Wakayama team in the years to come. After all, the Jurassic Park ride at Disney World is pretty cool, but we’re inclined to hold out for the real thing!

** Mammoth image courtesy of the WikiCommons Media project. Jurassic Park images are copyrighted by Warner Bros., and are presented here for the purposes of identification and/or critical commentary. **

Watching Seven Years in Tibet

I’ve been on somewhat of a movie spree lately–I think it may have just a little to do with my new Netflix account.

I don’t know why I haven’t seen Seven Years in Tibet, seeing as Tibet is near the top of my top dream destinations. The movie really exceeded my expectations, I guess it helps the story takes place during the 1940s, an action-packed period with WWII and the birth of modern China. Oh, and the whole annexation of Tibet thing.

What’s particularly well-done about the movie is how they played off the political issue. I didn’t think it was overly preachy; in fact, it really touched me how director David Thewlis chose to illustrate the oppression of the Tibetans by Communist Chinese. Watch the movie if you want to know more about their history and on-going plight.

And lastly, the landscapes are pretty gorgeous, though most of what you see was technically filmed in Argentina (there’s 20 minutes of footage secretly shot from within Tibet). On a lighter note, Brad Pitt was given the dubious honor of third worst accent in a movie for his portrayal of Heinrich Harrer.

Small yet significant tips to make your long-haul flights better

All my life I have traveled Economy Class (only once did I get lucky and got an upgrade to Business Class). In my opinion, flights of up to 7 hours in Economy are tolerable, but more than that and the all the fidgeting and frustration starts getting to you.

Having lived in Australia for 3 years, I dreaded the 14 hour flights to and from Dubai (30 hours if you include transfers and waiting); that’s when I realized how seemingly trivial things could drastically change the quality of your flight.

MSN just published an article listing some of these small yet significant tips, of which I think these are the most important:

Be comfortable:
Wear loose, warm, long, comfortable clothes. Stick to flat shoes, preferably ones you can wear socks with. Being warm and comfortable in your clothes will change the nature of your flight. (It’s such a basic point, I don’t understand why so many people choose to make a fashion statement on board at the expense of being comfortable. Perhaps they should stop making movies that make people believe they will find “the one” mid air.)

Bring lip-balm: Even if you have never-cracking lips, on a long-haul flight darling, they will crack! I carry lip-balm everyday, everywhere I go, and always have it on a flight. Once I forgot it and my lips chapped like tree bark. (Yes, ouch). I kept going to the bathroom and putting that disgusting hand-lotion they keep in there on my lips. Didn’t work, and yuck, never again.


Trail-mix:
I never thought of carrying trail-mix on a flight, and I am queen of trail-mix! I always have some on me. Muesli, raisins, walnuts, and M&M’s. Simple, energetic, healthy, and tasty — it’s a great idea to carry some on a flight.

Meal choice on board:
I eat everything and am generally easy with food. But on a flight I always get the not-so-good option (or maybe it’s just that the other food looks better because I don’t have it?). So the MSN article suggests to ask the air host/hostess to pick for you. Why? Because they eat that food too so they have a good idea which meal is better. Doh!

Here are some other tips from my side that are also gold for long-haul flights:

Choose a plane with Video-On-Demand:
If you can watch movies whenever you want, and can start them anytime you choose, you will not realize how quickly time flies. Video-On-Demand is becoming more and more common in-flight these days, but it’s worth double checking whether your flight has it before booking.

Don’t put the hot towel on your face:
Yes, yes, I know it feels awesome, but don’t forget how your skin feels after! It gets super dry and unless you have moisturizer or very greasy skin, the towel on your face can leave your skin quite uncomfortable for a while.

Chew gum to keep your ears from blocking: Well, they will still block, but to a lesser extent if you chew gum as you take-off and when landing, so keep some handy!

Getting into Business/First Class when you have an Economy ticket:
Caution — try this at your own risk. I have never done this and cannot guarantee results, but I have a friend who does it often and he often gets away with it.

Wait till the last, last, last boarding call. Then go running in pretending you are late. When you enter the flight, everyone has taken their seat and if there are empty seats in First Class or Business Class, odds are that those seats are free. That’s when you go and sit in one of them. If you are unlucky, it could be that the passenger who should be in that seat is in the bathroom before take-off, but key is to think positively and act confident. What’s the worse thing that can happen? You will be asked to go to your seat and you will suffer 5 seconds of embarrassment. No big deal.

Hope these tips help! Happy long flight!

‘Megacities’ Film Review: An eye-opening tour of the world’s greatest cities (part 2)

Read part 1 of my review.

Megacities in particular features a rather unorthodox audio track that escapes categorization. While Workingman’s Death employs a soundtrack composed by the industrialist musician John Zorn, Megacities relies on the “discarded” sounds of the local environments and cultures to fashion a coherent narrative voice. In this way, Glawogger becomes one of the refuse-combers that he films in Mexico City and Mumbai, gleaning what others in a global consumer society have left behind.

He astutely employs sound to highlight the absurdity of everyday situations-the squishing of headless chickens flapping around in a bloody oilcan, the overly-saccharine Latino pop music playing during the striptease, triumphant blares of unseen trumpets during an awkward photo shoot of Mexican soccer players, who happen to be standing next to a trash heap.
In Megacities, Glawogger also experiments with other audio narrative devices, such as replaying previous dialogue on a cassette player and verbalizing (although not in his own voice) what he imagines people on a Moscow subway are reading on their way to work. Such elements, including his emphasis on filming locals who are singing (even staging a scene in which one woman mouths the words of a Russian song into her phone), establish a lyrical, larger-than-life atmosphere that envelopes what would otherwise just be the unseemly underbellies of urban decay.

But Glawogger is sometimes not as circuitous in his objective; he occasionally voices his own belief through surrogates, as in the scene in which we hear a New York radio personality’s speel on living in the Big Apple, that it was “a city of disguises and masks. This city expands and collapses.”

Megacities may at first seem like a complete postmodern repudiation of traditional constraints on structure and conventions of storytelling. There is no narrative arc or character development (in the sense that they change through the course of the film). Glawogger admits that the first iteration would have surprised viewers even more, “I was collecting bits and pieces … the first cut that I showed to people, they thought it’s a confusing pile of images, and it took very long till it got its form.”

The finished form, through its minimalist structure of twelve snapshots of people and places around the world, speaks to the very nature of its subject: the global diaspora. By giving us hundreds of jumpy snippets of life in Moscow, New York, Mumbai, and Mexico City, Glawogger underlines the complexity behind these megacities, from the geopolitical to the cultural and sexual. He glorifies the diversity and bewilderment of the new world order, a place where you can walk two blocks and fall down the rabbit hole. To place these stories into neat little boxes with a storyline from A to B would be to attempt to simplify the indivisible.

But Glawogger does retain some semblance of structure in Megacities, most significantly in the use of motifs. In Mumbai, he finds a backroom shopfloor brimming with Indian workers sewing blue robes. In the next sequence in New York, we see these blue robes being hawked by a streetside vendor (in the DVD commentary, he admits to staging this New York segment). In another scene in Mumbai, he captures the image of a girl hidden away in an alleyway, holding a baby chick. Later in the film, we see a salesman selling baby chicks for a peso out of a rolling car to little kids.

Such connecting motifs highlight Glawogger’s thesis about how globalization has impacted every corner of the globe, from the slums of Mexico City to the slums of Mumbai. Thus, his editing choices reflect Nichol’s belief that “…images are not quite as unmanageable as they appear. They can be joined together with words or other images into systems of signs, and hence, meaning.” Glawogger has sewn these little patches of the everyday fabric of life into a flowing tapestry of the human condition.

Product Review: On-the-go business footwear (with Gore-Tex)

If you guys don’t know already, New Haven is a wet place. So I was really excited to find a pair of dress shoes made out of Gore-Tex. The Berlin GTX, which retails for about $200, have been an absolute critical part of my wardrobe. In fact, I just wore them to a lunch dinner with Ted Sorenson, one of JFK’s closest advisers (I did make the mistake of wearing jeans, but these shoes at least got me through the door).

Best of all, the GTX is really for people on the go. I’m thinking in particular of those long treks through the airport. My old pair really made my soles hurt just from the walk between the security checkpoint and the gate.

And if you somehow do get them wet–I’m thinking the only case this would happen is if you ford a river–the removable Ecco Comfort Fiber System (ok they might have went a little far with the marketing) means you’ll have a dry shoe in no time. But again, I can’t emphasis enough how clutch the Gore-Tex has been in keeping my feet dry; I think it also helps keeping everything down there aerated.

The only downside is the shoes came with the laces all mistied. I tried relacing, and this may be a sign of my stupidity rather than anything on Gore-Tex’s part, but even now, the laces pop out on the inside of the shoes. Again, I think I’m just rather thick-headed.

There’s a couple other styles that I’ve found on the Gore-Tex site.