Just before a big trip overseas, I cull my closet of those items of clothing that might have one more “wear” in them, and that are still appropriate for the destination to which I’m traveling. While on my trip, once that outfit has been worn, it goes straight into the hotel room trash bin.
Doing this means both one less laundry item when I get home AND it opens up space in my luggage for those obligatory souvenirs.
Don’t go overboard though… be sure to leave yourself enough clothes to cover an unexpected layover on your return home.