Most people visiting the Czech Republic–some 8 million annually–come only to Prague. For those trying to get away from all those tourists, I suggest heading to the south eastern part of the country: the wine growing region of Moravia. September is a great month to go because the wine harvest is in full-swing and wine-tastings readily available.
I am not going to lie to you. Don’t expect Napa Valley or Bordeaux. Don’t even bother with the red wines. Too cold for them. The whites, however, range from Pinot Blancs to Rieslings, and are generally very good. Above all, the wine cellars are all different and their owners tend to be generous, eclectic types.
You can also do a bicycle tour of Czech/Moravian wineries. Just remember as of last year, you can actually get a ticket when riding your bicycle drunk in the Czech Republic. Thankfully, no “open container” laws, yet.